Once and only once: mechanisms of centriole duplication and their deregulation in disease
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Once and only once: mechanisms of centriole duplication and their deregulation in disease.
Centrioles are conserved microtubule-based organelles that form the core of the centrosome and act as templates for the formation of cilia and flagella. Centrioles have important roles in most microtubule-related processes, including motility, cell division and cell signalling. To coordinate these diverse cellular processes, centriole number must be tightly controlled. In cycling cells, one new...
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V enous thrombosis is a fairly common disorder that manifests mainly as deep vein thrombosis of the leg or pulmonary embolism. It affects 1 in 1000 individuals annually and has a substantial mortality rate. 1 Its causes are both genetic (prothrombotic abnormalities sometimes referred to as a group as thrombophilia) and acquired. 2 Among the latter are cancer, female hormone use, and all forms o...
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The preparation for DNA replication initiation is tightly linked to cell-cycle progression, ensuring that replication occurs only once per cycle. The time is ripe for a molecular dissection of the links between the two processes.
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In Escherichia coli cells, the origin of chromosomal replication is temporarily inactivated after initiation has occurred. Origin sequestration is the first line of defence against over-initiation, providing a time window during which the initiation potential can be reduced by: (i) titration of DnaA proteins to newly replicated chromosomal elements; (ii) regulation of the activity of the DnaA i...
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Some events recur, and some happen only once. Galton refers to the latter as “once-only" events [1]. In a first-order logic of events that makes a type-token distinction, the possibility of concurrent occurrences of the same event renders the characterization of the intuitive once-onliness not very intuitive. In particular, the paradigmatic case of the nth occurrence of a recurring event is sho...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2018
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm.2017.127